| Identification | Back Directory | [Name]
CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE | [CAS]
160754-76-7 | [Synonyms]
CNS5161
CNS 5161
N-(2-Chloro-5-methylthiophenyl)-N''-(3-methylthiophenyl)-N''-methylguanidine
Guanidine, N''-[2-chloro-5-(methylthio)phenyl]-N-methyl-N-[3-(methylthio)phenyl]-
CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE | [Molecular Formula]
C16H18ClN3S2
| [MDL Number]
MFCD09833785 | [MOL File]
160754-76-7.mol | [Molecular Weight]
351.92 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellowish oil | [Uses]
CNS-5161 is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. | [in vivo]
In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1]. | [References]
[1] Walters MR, et al. Early clinical experience with the novel NMDA receptor antagonist CNS 5161. Br J Clin Pharmacol. 2002 Mar;53(3):305-11. DOI:10.1046/j.0306-5251.2001.01541.x |
|
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|