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T-10418 is an agonist for G2 accumulation protein (G2A) (also known as G protein-coupled receptor GPR132) with an EC50 of 0.82 μM. T-10418 exhibits a sensitizing effect on mouse primary sensory neurons. T-10418 exhibits good pharmacokinetic characteristics, and no obvious toxicity (at 100 μM) in mouse models[1]. | [References]
[1] Hernandez-Olmos V, et al., Development of a Potent and Selective G2A (GPR132) Agonist. J Med Chem. 2024 Jun 25. DOI:10.1021/acs.jmedchem.3c02164 |
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