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UDP-GlcNAz disodium is a sugar donor. UDP-GlcNAz disodium serves as a substrate for OGTase and O-GlcNAcase. UDP-GlcNAz disodium can glycosylate p62 and its glycosidic bond can be cleaved by O-GlcNAcase through catalysis. UDP-GlcNAz disodium can be used in the research of related protein glycosylation[1][2]. | [References]
[1] Vocadlo DJ, et, al. A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9116-21. DOI:10.1073/pnas.1632821100
[2] Kim EJ, et al. Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug Chem. 2014 Jun 18;25(6):1025-30. DOI:10.1021/bc5001774 |
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