1612158-07-2

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1612158-07-2 Structure

Identification	Back Directory
[Name] N-(Cyclopropylsulfonyl)-3-methyl-1-[5-(trifluoromethyl)-3-pyridinyl]-1H-indole-5-carboxamide
[CAS] 1612158-07-2
[Synonyms] DS43260857 N-(Cyclopropylsulfonyl)-3-methyl-1-[5-(trifluoromethyl)-3-pyridinyl]-1H-indole-5-carboxamide
[Molecular Formula] C19H16F3N3O3S
[MOL File] 1612158-07-2.mol
[Molecular Weight] 423.41

Chemical Properties	Back Directory
[density ] 1.53±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka] 3.90±0.20(Predicted)

Hazard Information	Back Directory
[Uses] DS43260857 is a potentNaV1.7inhibitor, which has a high inhibitory effect on both human and mouse NaV1.7. The IC50 values of DS43260857 for hNaV1.1, hNaV1.5, hNaV1.7, mNaV1.7 are 6.6, 14, 0.015 and 0.061 μM, respectively[1].
[References] [1] Narayan Karanjule, et al. N-Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors. ACS Med Chem Lett. 2023 May 24;14(6):788-793. DOI:10.1021/acsmedchemlett.3c00079

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