| Identification | Back Directory | [Name]
4-Piperidinecarboxamide, N,N-dimethyl-1-[4-(4-methyl-1H-pyrazol-1-yl)-3-pyridinyl]- | [CAS]
1613480-70-8 | [Synonyms]
Cholesterol 24-hydroxylase-IN-1
4-Piperidinecarboxamide, N,N-dimethyl-1-[4-(4-methyl-1H-pyrazol-1-yl)-3-pyridinyl]- | [Molecular Formula]
C17H23N5O | [MOL File]
1613480-70-8.mol | [Molecular Weight]
313.4 |
| Chemical Properties | Back Directory | [Boiling point ]
522.0±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.15±0.21(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier[1]. | [References]
[1] Kajita Y, et al. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J Med Chem. 2022;65(4):3343-3358. DOI:10.1021/acs.jmedchem.1c01898 |
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