| Identification | Back Directory | [Name]
4-CYANO-3-METHYLISOQUINOLINE | [CAS]
161468-32-2 | [Synonyms]
4-CYANO-3-METHYLISOQUINOLINE
4-Isoquinolinecarbonitrile, 3-methyl- | [Molecular Formula]
C11H8N2 | [MDL Number]
MFCD02179199 | [MOL File]
161468-32-2.mol | [Molecular Weight]
168.19 |
| Chemical Properties | Back Directory | [Boiling point ]
330.9±22.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO (50mg/ml) | [form ]
solid | [pka]
2.26±0.31(Predicted) | [color ]
white | [InChI]
1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3 | [InChIKey]
SZWLGBJCLZDZBY-UHFFFAOYSA-N | [SMILES]
n1cc2c(c(c1C)C#N)cccc2 |
| Hazard Information | Back Directory | [Uses]
4-Cyano-3-methylisoquinoline is an inhibitor for protein kinase A (PKA) with an IC50 of micromolar level. 4-Cyano-3-methylisoquinoline reverses morphine tolerance in mouse model[1]. | [Definition]
ChEBI: 3-methyl-4-isoquinolinecarbonitrile is a member of isoquinolines. | [Biological Activity]
Cell permeable: yes''Primary Target
PKA''Product competes with ATP.''Reversible: yes''Target IC50: 30 nM against protein kinase A | [storage]
+4°C | [References]
[1] Smith FL, et al., The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain Res. 2003 Sep 19;985(1):78-88. DOI:10.1016/s0006-8993(03)03170-6 |
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