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Antifungal agent 76 (compound 23h) exhibits potent activities and a broad antifungal spectrum with low MICs of 0.25-16 μg/mL. Antifungal agent 76 might achieve its rapid fungicidal activity by disrupting the fungal cell membrane[1]. | [References]
[1] Liu JC, et al. Natural phytoalexins inspired the discovery of new biphenyls as potent antifungal agents for treatment of invasive fungal infections. Eur J Med Chem. 2023 Sep 27;261:115842. DOI:10.1016/j.ejmech.2023.115842 |
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