| Identification | Back Directory | [Name]
PF-06726304 | [CAS]
1616287-82-1 | [Synonyms]
PF-6726304
PF-06726304
antitumor,H3K27me3,PF06726304,Karpas-422,EZH2,PF 06726304,Histone Methyltransferase,inhibit,Inhibitor,PF-06726304,Y641N
5,8-dichloro-2-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one,
1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-
5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | [Molecular Formula]
C22H21Cl2N3O3 | [MDL Number]
MFCD31563584 | [MOL File]
1616287-82-1.mol | [Molecular Weight]
446.33 |
| Chemical Properties | Back Directory | [Boiling point ]
686.8±55.0 °C(Predicted) | [density ]
1.333±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO : ≥ 15 mg/mL (33.61 mM) | [form ]
powder | [pka]
11.76±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor. |
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