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1616727-22-0

1616727-22-0 Structure

1616727-22-0 Structure
IdentificationBack Directory
[Name]

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]-
[CAS]

1616727-22-0
[Synonyms]

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]-
[Molecular Formula]

C36H54N8O10
[MOL File]

1616727-22-0.mol
[Molecular Weight]

758.86
Chemical PropertiesBack Directory
[Boiling point ]

1035.6±65.0 °C(Predicted)
[density ]

1.248±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

12.11±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[Biological Activity]

MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
[IC 50]

Protease Cleavable Linker; Cleavable Linker
[References]

[1]. Akaiwa M, et al. Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications. ACS Omega. 2018;3(5):5212-5221.
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