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1616752-12-5

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1616752-12-5 Structure

1616752-12-5 Structure

Identification	Back Directory
[Name] PDK4-IN-2
[CAS] 1616752-12-5
[Synonyms] PDK4-IN-2
[Molecular Formula] C13H10O5
[MOL File] 1616752-12-5.mol
[Molecular Weight] 246.22

Chemical Properties	Back Directory
[Boiling point ] 477.8±45.0 °C(predicted)
[density ] 1.392±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 5.84±0.20(predicted)

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[Uses] PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 of 46 μM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle[1].
[References] [1] Kenichi Aizawa, et al. A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction. Cells. 2023 Dec 30;13(1):87. DOI:10.3390/cells13010087

1616752-12-5 suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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