| Identification | Back Directory | [Name]
BENZAMIL HYDROCHLORIDE | [CAS]
161804-20-2 | [Synonyms]
Benzamil hydrochloride hydrate
Benzamil hydrate hydrochloride
N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide
N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrate hydrochloride
3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide,hydrochloride
3;5-DIAMINO-6-CHLORO-N-[IMINO[(PHENYLMETHYL)AMINO]METHYL]-2-PYRAZINECARBOXAMIDE; MONOHYDROCHLORIDE | [Molecular Formula]
C13H14ClN7OHCl | [MDL Number]
MFCD00069219 | [MOL File]
161804-20-2.mol | [Molecular Weight]
356.21 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
methanol: soluble10mg/mL | [form ]
solid | [color ]
yellow | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or may be stored at -20°C for up to 3 months. | [InChI]
1S/C13H14ClN7O.ClH.H2O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H;1H2 | [InChIKey]
YAJQRPFIYXRNKS-UHFFFAOYSA-N | [SMILES]
O.Cl.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)NCc2ccccc2 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Benzamil (161804-21-2) is a more potent (Ki = 10 nM vs 182 nM1, IC50 = 9 μM2) version of the epithelial sodium channel blocker Amiloride. It is also an inhibitor of Na+/Ca2+ exchange transport (IC50 = 11 μM)2 and the Na+/H+ antiporter (IC50 = 80 nM)2. | [Uses]
Benzamil Hydrochloride is a specific blocker of sodium channels. It also inhibits epithelial sodium channel (ENaC). Benzamil Hydrochloride is an analog of Amiloride (A578700). | [Biochem/physiol Actions]
Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels | [storage]
Store at +4°C | [References]
Cuthbert and Fanelli (1978), Effects of some pyrazinecarboxamides on sodium transport in frog skin; J. Pharmacol. 63 139
Kleyman and Cragoe (1988), Amiloride and Its Analogs as Tools in the Study of Ion Transport; Membrane Biol. 105 1 |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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