| Identification | Back Directory | [Name]
Talastine | [CAS]
16188-61-7 | [Synonyms]
Talastine
4-benzyl-2-[2-(dimethylamino)ethyl]phthalazin-1-one
4-Benzyl-2-[2-(dimethylamino)ethyl]phthalazin-1(2H)-one
1(2H)-Phthalazinone, 2-[2-(dimethylamino)ethyl]-4-(phenylmethyl)- | [Molecular Formula]
C19H21N3O | [MOL File]
16188-61-7.mol | [Molecular Weight]
307.39 |
| Chemical Properties | Back Directory | [Melting point ]
107-108 °C(Solv: water (7732-18-5); acetone (67-64-1)) | [Boiling point ]
bp0.3 215-222° | [density ]
1.11±0.1 g/cm3(Predicted) | [pka]
8.84±0.28(Predicted) |
| Hazard Information | Back Directory | [Uses]
Talastine is a potent H1-antihistamine. Talastine can induce allergic exanthema[1][2]. | [Definition]
ChEBI:Talastine is a member of phthalazines. | [References]
[1] Tao Huang, et al. A Barton nitrite ester-type remote functionalization and cyclization of N-nitrosobenzamides. Organic Chemistry Frontiers, 2023,10, 4559-4564.
[2] Richter G, et al. Talastine (Ahanon) as a cause of allergic drug exanthema. Dermatol Monatsschr. 1990;176(2-3):111-3. PMID:1973126 |
|
|