Identification | Back Directory | [Name]
helminthosporol | [CAS]
1619-29-0 | [Synonyms]
helminthosporol (1R,5S,8-anti)-8-Hydroxymethyl-1,7-dimethyl-4α-isopropylbicyclo[3.2.1]oct-6-ene-6-carbaldehyde Bicyclo[3.2.1]oct-6-ene-6-carboxaldehyde, 8-(hydroxymethyl)-1,7-dimethyl-4-(1-methylethyl)-, (1R,4R,5S,8S)- | [Molecular Formula]
C15H24O2 | [MOL File]
1619-29-0.mol | [Molecular Weight]
236.35 |
Hazard Information | Back Directory | [Uses]
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages[1][2][3]. | [References]
[1] Li YY, et al. Bioactive seco-Sativene Sesquiterpenoids from an Artemisia desertorum Endophytic Fungus, Cochliobolus sativus. J Nat Prod. 2020 May 22;83(5):1488-1494. DOI:10.1021/acs.jnatprod.9b01148 [2] Tamura S, et al. Isolation of helminthosporol as a natural plant growth-regulator and its chemical structure. Agricultural and Biological Chemistry, 1965, 29(3): 216-221. [3] PARK J K O O, et al. Inhibition of acyl-CoA: cholesterol acyltransferase by helminthosporol and its related compounds. The Journal of Antibiotics, 1993, 46(8): 1303-1305. |
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