| Hazard Information | Back Directory | [Uses]
Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2]. | [in vivo]
Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%[3]. | Animal Model: | Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[3] | | Dosage: | 5 mg/kg | | Administration: | IP; twice weekly (monday and wednesday) | | Result: | Reduced urinary γ-GT by 70-78%.
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| [storage]
4°C, stored under argon | [References]
[1] Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26. DOI:10.1039/c4sc02339k
[2] Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5. DOI:10.1016/0006-2952(95)00005-k
[3] Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60. DOI:10.1016/j.ntt.2008.02.006 |
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