| Chemical Properties | Back Directory | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
3.45±0.10(Predicted) | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe} |
| Hazard Information | Back Directory | [Uses]
(D)-PPA 1 is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy[1]. | [in vivo]
(D)-PPA 1 (2 mg/kg; s.c. or i.p.; once daily for 7 d) inhibits CT26 tumor growth in vivo in mice[1].
(D)-PPA 1 (40 μg/mouse in 200 μL; i.v.; single dose) has the ability to target to tumor tissue in CT26-tumor-bearing mice[1].
| Animal Model: | CT26-tumor-bearing Balb/c mice[1] | | Dosage: | 2 mg/kg | | Administration: | 1) Subcutaneous injection, for around the tumor once every day for 7 days
2) Intraperitoneal injection, once every day for 7 days
3) Intraperitoneal injection, once every day for 12 days; recorded the survival on day 13 | | Result: | Inhibited tumor growth, and prolonged the survival in mice. |
| [storage]
Store at -20°C | [References]
[1] Chang HN, et al. Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11760-4. DOI:10.1002/anie.201506225 |
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| Company Name: |
Combio (Suzhou) Ltd.
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| Telephone: |
17751201929; 17751201929 |
| Website: |
http://www.combiosz.com/ |
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