| Chemical Properties | Back Directory | [Boiling point ]
612.0±55.0 °C(Predicted) | [density ]
1.429±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [pka]
11.83±0.43(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
PF-6422899 is an irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR. | [Uses]
PF-6422899 is an inhibitor for EGFR, that it selectively binds to EGFR and SOAT1 in nanomolar levels[1]. | [References]
[1] van Bergen W, et al., Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs. ACS Chem Biol. 2024 Aug 16;19(8):1705-1718. DOI:10.1021/acschembio.3c00637 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|