| Identification | Back Directory | [Name]
SPSB2-iNOS inhibitory cyclic peptide-1 | [CAS]
1621616-13-4 | [Synonyms]
CP0
SPSB2-iNOS inhibitory cyclic peptide-1 | [Molecular Formula]
C35H56N12O14S2 | [MOL File]
1621616-13-4.mol | [Molecular Weight]
933.02 |
| Chemical Properties | Back Directory | [Boiling point ]
1673.971±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.455±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
4.007±0.10(predicted) | [color ]
White to off-white | [Sequence]
Ac-Cys-Val-Asp-Ile-Asn-Asn-Asn-Cys-NH2 (Disulfide bridge: Cys1-Cys8) |
| Hazard Information | Back Directory | [Uses]
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment[1]. | [References]
[1] Yap BK, et al., A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent. J Med Chem. 2014 Aug 28;57(16):7006-15. DOI:10.1021/jm500596j |
|
|