1621884-22-7

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1621884-22-7 Structure

Identification	Back Directory
[Name] AODDRWVLAXJCBA-UHFFFAOYSA-N
[CAS] 1621884-22-7
[Synonyms] PSI-7409 tetrasodium AODDRWVLAXJCBA-UHFFFAOYSA-N 2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate sodium salt
[Molecular Formula] C10H17FN2NaO14P3
[MDL Number] MFCD31657447
[MOL File] 1621884-22-7.mol
[Molecular Weight] 524.16

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[form ] Solid
[color ] White to off-white
[Water Solubility ] Water : ≥ 125 mg/mL (211.11 mM)

Hazard Information	Back Directory
[Uses] PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.
[References] [1] Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. DOI:10.1128/AAC.00399-10 [2] Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47. DOI:10.1074/jbc.M110.161802

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