| Identification | Back Directory | [Name]
1,2,4-Triazolo[4,3-b]pyridazine, 6-[(2,5-dimethoxyphenyl)thio]-3-(1-methyl-1H-pyrazol-4-yl)- | [CAS]
1622291-81-9 | [Synonyms]
PF-06371900
1,2,4-Triazolo[4,3-b]pyridazine, 6-[(2,5-dimethoxyphenyl)thio]-3-(1-methyl-1H-pyrazol-4-yl)- | [Molecular Formula]
C17H16N6O2S | [MOL File]
1622291-81-9.mol | [Molecular Weight]
368.41 |
| Hazard Information | Back Directory | [Uses]
PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor[1]. | [References]
[1] Henderson JL, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. DOI:10.1021/jm5014055 |
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