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1622327-37-0

1622327-37-0 Structure

1622327-37-0 Structure
IdentificationBack Directory
[Name]

Laprituximab Emtansine
[CAS]

1622327-37-0
[Synonyms]

Laprituximab Emtansine
Hazard InformationBack Directory
[Uses]

Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research[1][2][3].
[in vivo]

Laprituximab emtansine (1-5 mg/kg, i.v.) results tumor regression in EGFR-positive SCCHN xenograft model[4].

Animal Model:EGFR-positive SCCHN xenograft model[4]
Dosage:1, 2.5, 5 mg/kg
Administration:i.v.
Result:Resulted tumor regression with a minimally efficacious dose of 1 mg/kg, and highly active at 2.5 and 5 mg/kg.
[IC 50]

HER1
[References]

[1] Moradi-Kalbolandi S, et al. Monoclonal antibody-based therapeutics, targeting the epidermal growth factor receptor family: from herceptin to Pan HER. J Pharm Pharmacol. 2018 Jul;70(7):841-854. DOI:10.1111/jphp.12911
[2] Yulius Y. et al. Abstract 4513: IMGN289, an EGFR-targeting antibody-drug conjugate, is effective against tumor cells that are resistant to EGFR tyrosine kinase inhibitors. Cancer Res 1 October 2014; 74 (19_Supplement): 4513.
[3] Hyunseok Kang, et al. Antitumor effect of IMGN289, an anti-EGFR antibody-drug conjugate (ADC), in preclinical models of head and neck squamous cell carcinomas (HNSCC). Journal of Clinical Oncology. 2014. 32, no. 15_suppl.
[4] Jose F. Ponte, et al. Abstract 5483: Preclinical evaluation of IMGN289, an anti-EGFR antibody-maytansinoid conjugate for the treatment of squamous cell carcinoma of the head and neck. Cancer Res (2013) 73 (8_Supplement): 5483.
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