| Identification | Back Directory | [Name]
L-Lysine, L-lysyl-L-arginyl-L-phenylalanyl- | [CAS]
162290-78-0 | [Synonyms]
KRFK
L-Lysine, L-lysyl-L-arginyl-L-phenylalanyl- | [Molecular Formula]
C27H47N9O5 | [MOL File]
162290-78-0.mol | [Molecular Weight]
577.72 |
| Hazard Information | Back Directory | [Uses]
KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach[1]. | [in vivo]
KRFK (5 μg/5 μL/eyes; single dose) significantly prevents the development of chronic ocular surface inflammation in TSP-1-/- mice[1].
| [References]
[1] Soriano-Romaní L, et al. Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation. Int J Mol Sci. 2018 Dec 20;20(1):9. DOI:10.3390/ijms20010009 |
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