| Identification | Back Directory | [Name]
2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine | [CAS]
16234-15-4 | [Synonyms]
EOS-60342
2-chloro-4-(4-Morpholinyl)-
4-(2-Chlorothieno[3,2-d]pyrimidin-4-yl)
2-chloro-4-Morpholinothieno[3,2-d]pyriMidine
2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine
2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine
Thieno[3,2-d]pyriMidine, 2-chloro-4-(4-Morpholinyl)-
2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine-4 | [Molecular Formula]
C10H10ClN3OS | [MDL Number]
MFCD09909656 | [MOL File]
16234-15-4.mol | [Molecular Weight]
255.72 |
| Chemical Properties | Back Directory | [Boiling point ]
393.7±42.0 °C(Predicted) | [density ]
1.463 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
3.82±0.40(Predicted) | [InChI]
InChI=1S/C10H10ClN3OS/c11-10-12-7-1-6-16-8(7)9(13-10)14-2-4-15-5-3-14/h1,6H,2-5H2 | [InChIKey]
HKQMXHKNXRNUCF-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(N2CCOCC2)=C2SC=CC2=N1 |
| Questions And Answer | Back Directory | [Uses]
2-Chloro-4-(4-morpholino)thieno[3,2-D]pyrimidine is a pyrimidine derivative that can be used as a pharmaceutical and chemical intermediate. |
| Hazard Information | Back Directory | [Synthesis]
The reaction was carried out with 2,4-dichlorothieno[3,2-d]pyrimidine (64) (8.68 g, 42.34 mmol) and morpholine (8.1 mL, 2.2 eq.) in methanol (150 mL) with stirring for 1 hour at room temperature. After completion of the reaction, the reaction mixture was filtered and washed sequentially with water and methanol to afford the target compound 2-chloro-4-(4-morpholinyl)thieno[3,2-D]pyrimidine (65) as a white solid (11.04 g, 100% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 3.74 (4H, t, J = 4.9 Hz), 3.90 (4H, t, J = 4.9 Hz), 7.40 (1H, d, J = 5.6 Hz), 8.30 (1H, d, J = 5.6 Hz). | [References]
[1] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 29-30
[2] Patent: US2008/76768, 2008, A1. Location in patent: Page/Page column 7
[3] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 73
[4] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 133
[5] Patent: WO2008/73785, 2008, A2. Location in patent: Page/Page column 160 |
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