| Identification | Back Directory | [Name]
N-Biotinylaminoethyl Methanethiosulfonate | [CAS]
162758-04-5 | [Synonyms]
N-Biotinylaminoethyl methylthiosulphonate
2-[(Biotinoyl)-amino]-ethyl-methanthiosulfonat
Methanesulfonothioic Acid S-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]-1-oxopentyl]aMino]ethyl] Ester | [Molecular Formula]
C13H23N3O4S3 | [MDL Number]
MFCD01320376 | [MOL File]
162758-04-5.mol | [Molecular Weight]
381.53 |
| Chemical Properties | Back Directory | [Appearance]
White Fluffy Solid | [Melting point ]
95-103°C | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [Stability:]
Moisture Sensitive | [InChI]
InChI=1S/C13H23N3O4S3/c1-23(19,20)22-7-6-14-11(17)5-3-2-4-10-12-9(8-21-10)15-13(18)16-12/h9-10,12H,2-8H2,1H3,(H,14,17)(H2,15,16,18)/t9-,10-,12-/m0/s1 | [InChIKey]
CQPWMXNDGWWWHG-NHCYSSNCSA-N | [SMILES]
CS(SCCNC(=O)CCCC[C@H]1[C@@]2([H])NC(=O)N[C@@]2([H])CS1)(=O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
White Fluffy Solid | [Uses]
Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. MTSEA-biotin has
recently been used to probe the topology of the serotonin (5-HT) transporter by site-directed chemical labelling. | [Description]
MTSEA-biotin is a thiol-reactive probe that can be used to label proteins at cysteine residues.1,2 | [References]
[1] D. WAGNER C C. Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation[J]. The Journal of Neuroscience, 2001, 76 1: 67-74. DOI: 10.1523/jneurosci.21-01-00067.2001
[2] MING ZHONG. Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein.[J]. PLoS ONE, 2013: e73838. DOI: 10.1371/journal.pone.0073838 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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