| Identification | Back Directory | [Name]
HC-070 | [CAS]
1628291-95-1 | [Synonyms]
HC-070
HC-070
(HC070)
1H-Purine-2,6-dione, 8-(3-chlorophenoxy)-7-[(4-chlorophenyl)methyl]-3,7-dihydro-1-(3-hydroxypropyl)-3-methyl- | [Molecular Formula]
C22H20Cl2N4O4 | [MDL Number]
MFCD31657436 | [MOL File]
1628291-95-1.mol | [Molecular Weight]
475.32 |
| Chemical Properties | Back Directory | [Boiling point ]
695.4±65.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 62.5 mg/mL (131.49 mM) | [form ]
Solid | [pka]
14.85±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
HC-070 is a potent inhibitor of TRPC4 and TRPC5, leading to anxiolytic and antidepressant effects in mice. | [Uses]
HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively. | [in vivo]
HC-070 (1 mg/kg, p.o.) affects mice with increased evoked anxiety (CCK-4), but shows no effects in the absence of CCK-4. HC-070 (0.3, 1 or 3 mg/kg, p.o.) decreases anxiety in a standard EPM (more light/high anxiety). HC-070 (1 mg/kg) reduces the increased capacity for fear memory in mice subjected to chronic social stress on days 1-15. In addition, HC-070 (1, 3, 10 mg/kg, p.o.) causes reduction in marble burying behavior. HC-070 (0.3, 1, 3, 10 mg/kg, p.o.) also reduces time of immobility in a tail suspension test but does not impact locomotor activity in mice[1]. | [References]
[1] Just S, et al. Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225. DOI:10.1371/journal.pone.0191225 |
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