| Identification | Back Directory | [Name]
1-(1,2R-DIHEXADECANOYLPHOSPHATIDYL)INOSITOL-3,4,5-TRIPHOSPHATE, HEXASODIUM SALT | [CAS]
1628353-02-5 | [Synonyms]
PTDINS-(3,4,5)-P3 (1,2-DIPALMITOYL) SODIUM SALT
PHOSPHATIDYLINOSITOL-3,4,5-TRIPHOSPHATE C-16 SODIUM SALT
1-(1,2R-DIHEXADECANOYLPHOSPHATIDYL)INOSITOL-3,4,5-TRIPHOSPHATE, HEXASODIUM SALT | [Molecular Formula]
C41H83NaO22P4 | [MDL Number]
MFCD05863537 | [MOL File]
1628353-02-5.mol | [Molecular Weight]
1074.98 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
CHCl3:CH3OH:H2O (2.5:3:1): 3.8 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A lyophilized powder | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.3,4 Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references 5 and 6. | [Uses]
PtdIns-(345)-P3 (12-dipalmitoyl) sodium (Phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium) is a phosphatidylinositol 3,4,5-trisphosphate (PIP3) analog. PtdIns-(345)-P3 (12-dipalmitoyl) sodium can be incorporated in liposomes establish a backdrop of membrane phospholipids that closely mirrors in vivo conditions[1]. | [storage]
Store at -20°C | [References]
1. Lapetina, E.G., Billah, M.M., and Cuatrecasas, P. The phosphatidylinositol cycle and the regulation of arachidonic acid production Nature 292,367-369(1981).
2. Majerus, P.W. Inositol phosphate biochemistry Annu. Rev. Biochem. 61,225-250(1992).
3. Tanaka, K., Imajoh-Ohmi, S., Sawada, T., et al. A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains Eur. J. Biochem. 245,512-519(1997).
4. Yang, X., Rudolf, M., Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate J. Biol. Chem. 274(27),18973-18980(1999).
5. Pike, L.J., and Casey, L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains J. Biol. Chem. 271,26453-26456(1996).
6. Berridge, M.J. Inositol trisphosphate and calcium signalling Nature 361(6410),315-325(1993). |
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