| Identification | Back Directory | [Name]
L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-L-valyl-L-alanyl- | [CAS]
162852-62-2 | [Synonyms]
Z-Val-Ala-Asp
L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-L-valyl-L-alanyl- | [Molecular Formula]
C20H27N3O8 | [MOL File]
162852-62-2.mol | [Molecular Weight]
437.44 |
| Chemical Properties | Back Directory | [Boiling point ]
737.5±60.0 °C(Predicted) | [density ]
1.304±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.89±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Z-Val-Ala-Asp |
| Hazard Information | Back Directory | [Uses]
Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. Z-VAD induces both autophagy and necrosis in irradiated MDA-MB-231 and H460 mouse xenografts. Z-VAD with radiation produces a significant tumor growth delay and shows dramatic antiangiogenic effect in cancer xenograft[1]. | [References]
[1] Luigi Moretti, et al. Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor. Mol Cancer Ther. 2009 May;8(5):1270-9. DOI:10.1158/1535-7163.MCT-08-0893 |
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