| Identification | Back Directory | [Name]
Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- | [CAS]
1628784-54-2 | [Synonyms]
BG47
BG-47
BG 47
Benzamide, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-N-[2-hydroxy-5-(2-thienyl)phenyl]- | [Molecular Formula]
C25H22N4O2S | [MOL File]
1628784-54-2.mol | [Molecular Weight]
442.53 |
| Hazard Information | Back Directory | [Description]
BG47 is a novel probe for chemo-optical modulation of epigenetically regulated transcription (COMET). It enables high-resolution, optical control of epigenetic mechanisms and photochromically inhibits human histone deacetylases using visible light. | [Uses]
BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research[1]. | [IC 50]
HDAC1; HDAC2 | [References]
[1] Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23. DOI:10.1038/nchembio.2042 |
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