| Identification | Back Directory | [Name]
gne-131 | [CAS]
1629063-81-5 | [Synonyms]
gne-131
CS-2887
GNE-131;GNE131;GNE 131
N-[6-Cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide
Cyclopropanesulfonamide, N-[6-cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]- | [Molecular Formula]
C23H30N4O3S | [MOL File]
1629063-81-5.mol | [Molecular Weight]
442.57 |
| Chemical Properties | Back Directory | [density ]
1.70±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (282.44 mM) | [form ]
Solid | [pka]
4.06±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. | [in vivo]
GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain[1]. | [IC 50]
Nav1.7: 3 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14 DOI:10.1021/acs.jmedchem.7b01826 |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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