| Identification | Back Directory | [Name]
Integrin Antagonist 1 (hydrochloride) | [CAS]
1629249-40-6 | [Synonyms]
GSK-3008348 hydrochloride
Integrin Antagonist 1 (hydrochloride)
(3S)-3-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl]-4-{(3S)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-1-pyrrolidinyl}butanoic acid | [Molecular Formula]
C29H38ClN5O2 | [MDL Number]
MFCD29924721 | [MOL File]
1629249-40-6.mol | [Molecular Weight]
524.11 |
| Hazard Information | Back Directory | [Uses]
GSK 3008348 hydrochloride is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7). | [References]
[1] Anderson Niall Andrew, et al. Preparation of naphthyridine derivatives useful as αvβ6 integrin antagonists. From PCT Int. Appl. (2014), WO 2014154725 A1 20141002. |
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| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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