| Identification | Back Directory | [Name]
BAR 501 impurity | [CAS]
1632118-70-7 | [Synonyms]
BAR 501 impurity
(3alpha,5beta,6beta,7alpha)-6-Ethylcholane-3,7,24-triol
(3R,5S,6S,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-[(2R)-5-hydroxypentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol | [Molecular Formula]
C26H46O3 | [MDL Number]
MFCD30747751 | [MOL File]
1632118-70-7.mol | [Molecular Weight]
406.64 |
| Chemical Properties | Back Directory | [Boiling point ]
527.6±25.0 °C(Predicted) | [density ]
1.047±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/mL; DMSO: 100μg/ml; Ethanol: 2 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 500μg/ml | [form ]
A crystalline solid | [pka]
14.82±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay.1
| [Uses]
(3α, 5β, 6β, 7α)-BAR501 (BAR504-6b) is a compound having cholane scaffolds of formula. (3α, 5β, 6β, 7α)-BAR501 can be used for the research of FXR and TGR5/GPBAR1 mediated diseases[1]. | [References]
1. Festa, C., Renga, B., D'Amore, C., et al. Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands J. Med. Chem. 57(20),8477-8495(2014). |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
ABBIOCHEM
|
| Tel: |
18964309092 18964309092 |
| Website: |
http://www.abbiochemical.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|