| Identification | Back Directory | [Name]
Dapsone-13C12 | [CAS]
1632119-29-9 | [Synonyms]
Dapson 13C12
Dapsone-13C12
4,4′-Sulfonyldianiline-13C12
Bis(4-aminophenyl-13C6) sulfone
4,4′-Diaminodiphenyl-13C12 sulfone | [Molecular Formula]
C12H12N2O2S | [MOL File]
1632119-29-9.mol | [Molecular Weight]
260.21 |
| Chemical Properties | Back Directory | [density ]
1.362±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [InChI]
InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1,11+1,12+1 | [InChIKey]
MQJKPEGWNLWLTK-WCGVKTIYSA-N | [SMILES]
S([13C]1[13CH]=[13CH][13C](=[13CH][13CH]=1)N)([13C]1[13CH]=[13CH][13C](=[13CH][13CH]=1)N)(=O)=O |
| Hazard Information | Back Directory | [Uses]
Dapsone-13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[1][2][3][4][5]. | [Definition]
ChEBI: Dapsone is a sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It has a role as an antimalarial, a leprostatic drug, an antiinfective agent and an anti-inflammatory drug. It is a sulfone and a substituted aniline. It is functionally related to a diphenyl sulfone. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol DOI:10.1067/mjd.2001.114733
[3] Dapsone, Drug.com
[4] D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9. DOI:10.1093/infdis/169.2.456
[5] Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607. DOI:10.3390/pharmaceutics11110607 |
|
| Company Name: |
BOC Sciences Gold
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|