| Identification | Back Directory | [Name]
INECALCITOL | [CAS]
163217-09-2 | [Synonyms]
INECALCITOL
Ridinilazole
(7E)-19-Nor-9,10-seco-14b-cholesta-5,7-dien-23-yne-1a,3b,25-triol
1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aR,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-diMethyl-3-hexyn-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-,(1R,3R)-
(1R,3R)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol | [Molecular Formula]
C26H40O3 | [MDL Number]
MFCD09837757 | [MOL File]
163217-09-2.mol | [Molecular Weight]
400.59 |
| Chemical Properties | Back Directory | [Boiling point ]
568.6±50.0 °C(Predicted) | [density ]
1.163 | [storage temp. ]
4°C, protect from light, stored under nitrogen | [solubility ]
DMSO: Soluble | [form ]
Solid | [pka]
13.12±0.29(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Inecalcitol is a derivative of Vitamin D (V676045), the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. It occurs in and is isolated from fish liver oils. | [storage]
4°C, protect from light, stored under nitrogen | [References]
[1] GUY EELEN. Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.[J]. Molecular Pharmacology, 2005, 67 5: 1566-1573. DOI: 10.1124/mol.104.008730
[2] L VERLINDEN. Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo.[J]. Cancer research, 2000, 60 10: 2673-2679.
[3] PETRA DE HAES . 1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage[J]. Journal of photochemistry and photobiology. B, Biology, 2005, 78 2: Pages 141-148. DOI: 10.1016/j.jphotobiol.2004.09.010
[4] MICHAEL S K WONG. Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.[J]. American journal of physiology. Heart and circulatory physiology, 2008, 295 1: H289-96. DOI: 10.1152/ajpheart.00116.2008 |
|
|