| Identification | Back Directory | [Name]
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-2,3,9-trimethyl-, (6S)- | [CAS]
1635437-52-3 | [Synonyms]
4-(4-Chlorophenyl)-N-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-2,3,9-trimethyl-, (6S)- | [Molecular Formula]
C39H53ClN8O6S2 | [MDL Number]
MFCD22683750 | [MOL File]
1635437-52-3.mol | [Molecular Weight]
829.47 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, stored under nitrogen | [solubility ]
DMSO : 180 mg/mL (217.01 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.90±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50?of 0.4 μM[1]. | [Biological Activity]
Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM[1].
Biotinylated-JQ1 (0.1 nM-100 μM; 72 hours) inhibits MM1.S cell proliferation with an EC50 of 0.4 μM[1]. | [References]
[1]. Lars Anders, et al. Genome-wide localization of small molecules. Nat Biotechnol. 2014 Jan;32(1):92-6. |
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