| Identification | Back Directory | [Name]
glutathione sulfonate | [CAS]
1637-70-3 | [Synonyms]
glutathione sulfonate
Glycine, L-γ-glutamyl-S-sulfo-L-cysteinyl- | [Molecular Formula]
C10H17N3O9S2 | [MOL File]
1637-70-3.mol | [Molecular Weight]
387.39 |
| Hazard Information | Back Directory | [Uses]
Glutathione sulfonate (S-Sulfoglutathione) is a multifunctional bioactive compound that inhibits angiogenesis and tumor growth. Glutathione sulfonate is a competitive inhibitor of glutathione S-transferase and is involved in the detoxification process and the binding of a variety of exogenous and endogenous compounds. Glutathione sulfonate acts in the substrate binding site of Escherichia coli glutathione S-transferase, affecting the catalytic mechanism. The structural characteristics of Glutathione sulfonate contribute to its inhibitory effect by hydrogen bonding in the active center of the enzyme[1]. | [Definition]
ChEBI: Glutathione sulfonate is a S-substituted glutathione, a L-cysteine derivative and a tripeptide. | [References]
[1] Three-dimensional structure of Escherichia coli glutathione S-transferase complexed with glutathione sulfonate: catalytic roles of Cys10 and His106 |
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