| Identification | Back Directory | [Name]
L-Prolinamide, 3-methyl-N-[(2E)-1-oxo-3-[4-(phosphonooxy)phenyl]-2-buten-1-yl]-L-valyl-N-(4-iodophenyl)-N-phenyl- | [CAS]
1637532-68-3 | [Synonyms]
STAT6-IN-1
L-Prolinamide, 3-methyl-N-[(2E)-1-oxo-3-[4-(phosphonooxy)phenyl]-2-buten-1-yl]-L-valyl-N-(4-iodophenyl)-N-phenyl- | [Molecular Formula]
C33H37IN3O7P | [MOL File]
1637532-68-3.mol | [Molecular Weight]
745.54 |
| Hazard Information | Back Directory | [Uses]
STAT6-IN-1 (Compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 μM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1][2][3]. | [References]
[1] Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58(22):8970-84. DOI:10.1021/acs.jmedchem.5b01321
[2] John S, et al. Stat6 inhibitors. Patent WO2014182928A2.
[3] Zhang F, et al. Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment. Bioact Mater. 2023 Aug 14;31:231-246. DOI:10.1016/j.bioactmat.2023.08.008 |
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