| Identification | Back Directory | [Name]
4-AMINOBENZOOXAZOL
| [CAS]
163808-09-1 | [Synonyms]
4-BenzoxazolaMine
4-AMINOBENZOOXAZOL
4-Aminobenzoxazole
4-Aminobenzooxazole
Benzooxazol-4-ylamine
Benzo[d]oxazol-4-aMine
1,3-Benzoxazol-4-amine hydrochloride
1,3-Benzoxazol-4-amine, 4-Aminobenzo[d]oxazole | [Molecular Formula]
C7H6N2O | [MDL Number]
MFCD00973373 | [MOL File]
163808-09-1.mol | [Molecular Weight]
134.14 |
| Chemical Properties | Back Directory | [Melting point ]
77-79° | [Boiling point ]
282.3±13.0 °C(Predicted) | [density ]
1.317±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.16±0.30(Predicted) | [Appearance]
Brown to dark brown Solid |
| Hazard Information | Back Directory | [Synthesis]
(b) Synthesis of 4-aminobenzoxazole: The crude product 4-nitrobenzoxazole described above was suspended with Pd/C (5%, 0.51 g) in MeOH (50 mL). The mixture was placed under H2 (50 psi) atmosphere and the reaction was shaken at room temperature overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth layer and the filter cake was washed with MeOH. The filtrate was concentrated under reduced pressure to give 6.87 g of light brown solid product (100% yield). The product was characterized by 1H NMR (CDCl3): δ 7.96 (s, 1H), 7.16 (t, J = 8.1 Hz, 1H), 6.95 (dd, J = 0.9,8.1 Hz, 1H), 6.61 (dd, J = 0.6,8.1 Hz, 1H), 4.33 (brs, 2H). | [References]
[1] Patent: US2006/104998, 2006, A1. Location in patent: Page/Page column 19
[2] Dalton Transactions, 2012, vol. 41, # 21, p. 6507 - 6515
[3] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0110; 0111
[4] Heterocycles, 1995, vol. 41, # 2, p. 345 - 352 |
|
|