| Identification | Back Directory | [Name]
LY-3154207 | [CAS]
1638667-79-4 | [Synonyms]
LY-3154207
LY-3154207,LY3154207
2-(2,6-dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one | [Molecular Formula]
C24H29Cl2NO3 | [MDL Number]
MFCD32215335 | [MOL File]
1638667-79-4.mol | [Molecular Weight]
450.4 |
| Chemical Properties | Back Directory | [Boiling point ]
628.4±55.0 °C(Predicted) | [density ]
1.245±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 110 mg/mL (244.23 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.60±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor
positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM)[1]. | [storage]
Store at -20°C | [References]
[1] Hao J, Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Po DOI:10.1021/acs.jmedchem.9b01234 |
|
|