| Identification | Back Directory | [Name]
1H-Indole-3-butanoic acid, β-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]amino]-, (βS)- | [CAS]
1639159-47-9 | [Synonyms]
UniPR129
Uni-PR-129
Uni PR 129
1H-Indole-3-butanoic acid, β-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]amino]-, (βS)- | [Molecular Formula]
C36H52N2O4 | [MOL File]
1639159-47-9.mol | [Molecular Weight]
576.82 |
| Chemical Properties | Back Directory | [Boiling point ]
781.0±55.0 °C(Predicted) | [density ]
1.162±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.39±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UniPR129 is a potent Eph/ephrin antagonist with IC50s of 0.84-3.01 μM. UniPR129 has the potential for the research of cancer disease[1][2]. | [Biological Activity]
UniPR129 is a potent Eph/ephrin antagonist. UniPR129 has the potential for the research of cancer disease[1]. | [IC 50]
EphA1: 1.39 μM (IC50); EphA2: 1.12 μM (IC50); EphA3: 1.43 μM (IC50); EphA4: 1.58 μM (IC50); EphA5: 1.57 μM (IC50); EphA6: 1.53 μM (IC50); EphA7: 1.24 μM (IC50); EphA8: 0.84 μM (IC50); EphB1: 2.75 μM (IC50); EphB2: 2.96 μM (IC50); EphB3: 3.74 μM (IC50); EphB4: 2.60 μM (IC50); EphB5: 3.01 μM (IC50) | [storage]
Store at -20°C | [References]
[1]. Giorgio C, et al. Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction. Biochem Pharmacol. 2018;147:21-29. |
|
|