| Identification | Back Directory | [Name]
Sigma-1 receptor antagonist 2 | [CAS]
1639220-15-7 | [Synonyms]
Sigma-1 receptor antagonist 2
Pyrimidine, 5-chloro-2-(4-methoxyphenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]-
Sigma-1 receptor antagonist 2,Sigma1 receptor antagonist 2,Sigma 1 receptor antagonist 2,Sigma Receptor,Inhibitor,inhibit | [Molecular Formula]
C20H26ClN3O2 | [MDL Number]
MFCD32215323 | [MOL File]
1639220-15-7.mol | [Molecular Weight]
375.89 |
| Chemical Properties | Back Directory | [Boiling point ]
449.3±45.0 °C(Predicted) | [density ]
1.160±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 86.67 mg/mL (230.57 mM) | [form ]
Solid | [pka]
8.96±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1]. | [IC 50]
Sigma 1 Receptor | [storage]
Store at -20°C | [References]
[1] Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23. DOI:10.1021/jm501207r |
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