| Identification | Back Directory | [Name]
TH588 (hydrochloride) | [CAS]
1640282-30-9 | [Synonyms]
TH588 HCl
TH588 (hydrochloride)
4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine
6-(2,3-dichlorophenyl)-N4-cyclopropylpyrimidine-2,4-diamine hydrochloride | [Molecular Formula]
C13H13Cl3N4 | [MDL Number]
MFCD28347840 | [MOL File]
1640282-30-9.mol | [Molecular Weight]
331.63 |
| Hazard Information | Back Directory | [Uses]
TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). | [in vivo]
TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1]. | Animal Model: | 5-6 weeks female SCID mice (SW480 xenograft cancer model)[1] | | Dosage: | 30 mg/kg | | Administration: | Subcutaneous injection (s.c.); once daily for 35 days | | Result: | Reduced tumour growth in SW480 xenograft cancer model. |
| [References]
[1] Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21. DOI:10.1038/nature13181 |
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Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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