ChemicalBook--->CAS DataBase List--->1640282-30-9

1640282-30-9

1640282-30-9 Structure

1640282-30-9 Structure
IdentificationBack Directory
[Name]

TH588 (hydrochloride)
[CAS]

1640282-30-9
[Synonyms]

TH588 HCl
TH588 (hydrochloride)
4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine
6-(2,3-dichlorophenyl)-N4-cyclopropylpyrimidine-2,4-diamine hydrochloride
[Molecular Formula]

C13H13Cl3N4
[MDL Number]

MFCD28347840
[MOL File]

1640282-30-9.mol
[Molecular Weight]

331.63
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Uses]

TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
[in vivo]

TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1].

Animal Model:5-6 weeks female SCID mice (SW480 xenograft cancer model)[1]
Dosage:30 mg/kg
Administration:Subcutaneous injection (s.c.); once daily for 35 days
Result:Reduced tumour growth in SW480 xenograft cancer model.
[References]

[1] Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21. DOI:10.1038/nature13181
1640282-30-9 suppliers list
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207 , +8617767106207
Website: https://www.molcore.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Musechem  
Tel: +1-800-259-7612
Website: www.musechem.com
Company Name: Absin Bioscience Inc.  
Tel: 021-38015121 18438616290
Website: www.absin.cn/
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Tel: 15865264761
Website: www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Adooq Bioscience LLC  
Tel: 400-025-6535
Website: http://www.adooq.cn
Company Name: Biorbyt Ltd.  
Tel: +44 (0)1223 859 353
Website: http://www.biorbyt.com
Company Name: Axon Medchem LLC  
Tel: 703 - 9861
Website: www.axonmedchem.com
Company Name: Frontier Scientific, Inc.  
Tel: 435 753 1901
Website: www.frontiersci.com
Company Name: Guangzhou Baben Biotechnology Co., Ltd.  
Tel: 17130848100
Website: www.chemicalbook.com/ShowSupplierProductsList1684271/0_EN.htm
Company Name: Foshan Minghua Biotechnology Co., Ltd.  
Tel: 18312287787
Website: www.chemicalbook.com/ShowSupplierProductsList424309/0_EN.htm
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 15850508050
Website: http://www.synzest.com
Tags:1640282-30-9 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.