| Identification | Back Directory | [Name]
formycin triphosphate | [CAS]
16409-13-5 | [Synonyms]
formycin triphosphate
D-Ribitol, 1-C-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-, 5-(tetrahydrogen triphosphate), (1S)- | [Molecular Formula]
C10H16N5O13P3 | [MOL File]
16409-13-5.mol | [Molecular Weight]
507.18 |
| Hazard Information | Back Directory | [Uses]
Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC50 at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 at about 100 μM[1][2]. | [References]
[1] P V Attwood, et al. Interaction of formycin A-5'-triphosphate with pyruvate carboxylase. FEBS Lett. 1984 Sep 17;175(1):45-50. DOI:10.1016/0014-5793(84)80566-9
[2] C H Chang, et al. Formycin triphosphate as a probe for the ATP binding site involved in the activation of guanylate cyclase. Eur J Pharmacol. 1992 Oct 1;227(2):229-31. DOI:10.1016/0922-4106(92)90133-g |
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