| Identification | Back Directory | [Name]
L-Lysinamide, N-[2-[4-[4-(2-methyl-1H-imidazol-1-yl)butyl]phenyl]acetyl]-L-seryl-N-(2-cyclohexylethyl)- | [CAS]
164931-25-3 | [Synonyms]
SC58272
SC-58272
SC 58272
L-Lysinamide, N-[2-[4-[4-(2-methyl-1H-imidazol-1-yl)butyl]phenyl]acetyl]-L-seryl-N-(2-cyclohexylethyl)- | [Molecular Formula]
C33H52N6O4 | [MOL File]
164931-25-3.mol | [Molecular Weight]
596.8 |
| Hazard Information | Back Directory | [Description]
SC-58272 is an antifungal NMT inhibitor. N-myristoyltransferase (Nmt) attaches myristate to the N-terminal glycine of many important eukaryotic and viral proteins. It is a target for anti-fungal and anti-viral therapy. | [Uses]
SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC50 of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme[1]. | [References]
[1] Jennifer K Lodge, et al. N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. Microbiology (Reading). 1997 Feb:143 ( Pt 2):357-366. DOI:10.1099/00221287-143-2-357 |
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