1649479-05-9

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[Name] GRC-17536
[CAS] 1649479-05-9
[Synonyms] GRC17536 GRC-17536 GRC 17536

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[Description]

GRC-17536 is an orally available, potent and selective inhibitor of Transient Receptor Potential Ankyrin 1 (TRPA1) with IC50 value less than 10 nM. GRC-17536 shows more than 1000 fold selectivity over other TRPs, a large panel of GPCRs, enzymes and other ion channels. GRC-17536 has proven highly efficacious in treating inflammatory and neuropathic pain in animal models compared to other commercial drugs.

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