| Identification | Back Directory | [Name]
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride | [CAS]
16496-99-4 | [Synonyms]
Dehydroabietylamine Hydrochloride
DehydroabiethylaMine Hydrochloride
(+)-DehydroabiethylaMine Hydrochloride
13-Isopropyl-podocarpa-8,11,13-trien-15-aMine Hydrochloride
((1S,4aS)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methanamine hydrochloride
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride | [Molecular Formula]
C20H32ClN | [MOL File]
16496-99-4.mol | [Molecular Weight]
321.928 |
| Chemical Properties | Back Directory | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 9 mg/ml). | [form ]
solid | [color ]
Off-white or beige | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1?Induces apoptosis in breast cancer2, melanoma3?and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5?Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 μM.6 | [Uses]
Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans. | [IC 50]
CB1 | [References]
[1] OMER F KUZU. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.[J]. Molecular Cancer Therapeutics, 2014, 13 7: 1690-1703. DOI:10.1158/1535-7163.mct-13-0868
[2] ANURADHA SEHRAWAT. Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation.[J]. Molecular Carcinogenesis, 2017, 56 2: 337-348. DOI:10.1002/mc.22497
[3] YU-CHI CHEN. Targeting cholesterol transport in circulating melanoma cells to inhibit metastasis[J]. Pigment Cell & Melanoma Research, 2017, 30 6: 541-552. DOI:10.1111/pcmr.12614
[4] KRISHNA B SINGH Shivendra V S Xinhua Ji. Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer.[J]. Molecular Cancer Therapeutics, 2018, 17 10: 2079-2090. DOI:10.1158/1535-7163.mct-18-0117
[5] JUHEE SIM. Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer[J]. Archives of Pharmacal Research, 2014, 38 5: 725-733. DOI:10.1007/s12272-014-0443-0
[6] THOMAS D. AICHER ∗. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)[J]. Bioorganic & Medicinal Chemistry Letters, 1999, 9 15: Pages 2223-2228. DOI:10.1016/s0960-894x(99)00380-7 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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