| Identification | Back Directory | [Name]
[[(2R,3R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-oxolan-2 -yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid | [CAS]
16506-88-0 | [Synonyms]
2-Cl-ADP
2-chloro-ADP
2-CHLOROADENOSINE-5'-O-DIPHOSPHATE(2-CL-5'-ADP)
Adenosine 5'-(trihydrogen diphosphate), 2-chloro-
[(2R,3S,4R,5R)-5-(6-amino-2-chloropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
[[(2R,3R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-oxolan-2 -yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid | [Molecular Formula]
C10H14ClN5O10P2 | [MOL File]
16506-88-0.mol | [Molecular Weight]
461.65 |
| Hazard Information | Back Directory | [Uses]
2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sis a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase[1]. 2-Chloro-ADP inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM[2]. | [References]
[1] N J Cusack, et al. Competitive inhibition by adenosine 5'-triphosphate of the actions on human platelets of 2-chloroadenosine 5'-diphosphate, 2-azidoadenosine 5'-diphosphate and 2-methylthioadenosine 5'-diphosphate. Br J Pharmacol. 1982 Oct;77(2):329-33. DOI:10.1111/j.1476-5381.1982.tb09302.x
[2] Mitchell A Moseng, et al. 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. FEBS Lett. 2019 Aug;593(15):2030-2039. DOI:10.1002/1873-3468.13475 |
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