| Identification | Back Directory | [Name]
7H-8,15b-Methano-1H,3H,12H-benzo[de]cyclohepta[1,2-g:3,4,5-d'e']bis[2]benzopyran-3,7,12-trione, 16-(acetyloxy)-8,8a,15,15a-tetrahydro-4,11,14-trihydroxy-8a-methoxy-6,9-dimethyl-, (8S,8aS,15aR,15bR,16S)- | [CAS]
1658474-60-2 | [Synonyms]
Talaromycesone A
7H-8,15b-Methano-1H,3H,12H-benzo[de]cyclohepta[1,2-g:3,4,5-d'e']bis[2]benzopyran-3,7,12-trione, 16-(acetyloxy)-8,8a,15,15a-tetrahydro-4,11,14-trihydroxy-8a-methoxy-6,9-dimethyl-, (8S,8aS,15aR,15bR,16S)- | [Molecular Formula]
C29H24O11 | [MDL Number]
MFCD33021595 | [MOL File]
1658474-60-2.mol | [Molecular Weight]
548.49 |
| Chemical Properties | Back Directory | [Boiling point ]
880.9±65.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
A solid | [pka]
7.21±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC50 of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC50 of 7.49 μM[1]. | [Biological Activity]
Talaromycesone A is a fungal metabolite originally isolated from Talaromyces.1 It is active against S. epidermidis and methicillin-resistant S. aureus (MRSA) bacteria (IC50s = 3.70 and 5.48 μM, respectively). Talaromycesone A inhibits acetylcholinesterase (AChE) in a cell-free assay (IC50 = 7.49 μM for the human enzyme). | [References]
1.Wu, B., Ohlendorf, B., Oesker, V., et al.Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458Mar. Biotechnol. (NY)17(1)110-119(2015)
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