| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [Sequence]
Ac-Val-Pro-{Phe(3-Cl)}-{Hcy}-Leu-Arg-Lys-{Nle}-Pro-Ala-Ser-Phe-Cys-Lys-Pro-Pro-Glu-NH2 (Disulfide bridge:Hcy4-Cys13) |
| Hazard Information | Back Directory | [Uses]
YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of?YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1]. | [Biological Activity]
YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer polypeptide with higher binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM). | [in vitro]
YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD(1209-426) in a GST pull-down assay, the K d < /sub> of His-YAP(1209-426) is determined to be 40 nM. | [target]
IC50: 25 nM (YAP-TEAD interaction) | [IC 50]
YAP/TAZ | [References]
[1] Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8. DOI:10.1021/ml500160m |
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