| Hazard Information | Back Directory | [Description]
CRT-0105446 is a potent LIMK inhibitor. It acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells. | [Uses]
CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM[1]. | [References]
[1] Mark D Charles, et al. Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties. J Med Chem. 2015 Oct 22;58(20):8309-13. DOI:10.1021/acs.jmedchem.5b01242 |
|
|