| Identification | Back Directory | [Name]
4-(4-bromo-1H-pyrazol-3-yl)pyridine | [CAS]
166196-54-9 | [Synonyms]
181179
4-(4-Bromo-1h-pyrazol-3-yl)pyridin
4-(4-bromo-1H-pyrazol-3-yl)pyridine
Pyridine, 4-(4-bromo-1H-pyrazol-3-yl)-
4-(4-bromo-1H-pyrazol-5-yl)pyridine(SALTDATA: FREE) | [Molecular Formula]
C8H6BrN3 | [MDL Number]
MFCD14657915 | [MOL File]
166196-54-9.mol | [Molecular Weight]
224.06 |
| Hazard Information | Back Directory | [Uses]
HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily[1]. | [References]
[1] Xiaoli Wei, et al. Fragment-based discovery of small molecule inhibitors of the HDGFRP2 PWWP domain. FEBS Lett. 2024 Jul 19.1873-3468.14981. DOI:10.1002/1873-3468.14981 |
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