| Identification | Back Directory | [Name]
NTE-122 DIHYDROCHLORIDE | [CAS]
166967-84-6 | [Synonyms]
NTE-122 DIHYDROCHLORIDE
trans-1,4-Bis[[1-cyclohexyl-3-(4-dimethylaminophenyl)ureido]methyl]cyclohexane dihydrochloride | [Molecular Formula]
C38Cl2H60N6O2 | [MDL Number]
MFCD07370144 | [MOL File]
166967-84-6.mol | [Molecular Weight]
703.83 |
| Hazard Information | Back Directory | [Uses]
NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1]. | [References]
[1] Y Azuma, et al. NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits. Jpn J Pharmacol. 2001 May;86(1):120-3. DOI:10.1254/jjp.86.120 |
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